The oxidation of homophthalimide derivatives by dioxygen in alkaline media and cleavage-cyclisation reactions

H Heaney, M O Taha, A M Z Slawin

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10 Citations (Scopus)

Abstract

The oxidation of alpha-alkylhomophthalimide derivatives by dioxygen in the presence of ethanolic sodium hydroxide leads to the rapid formation of alpha-hydroxy-alpha-alkylhomophthalimide derivatives and hence, as a result of ring cleavage and lactone formation, to alpha-amido-alpha-alkylphthalides, potential precursors to phthalide isoquinoline alkaloids and analogues. (C) 1997 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)3051-3054
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number17
Publication statusPublished - 28 Apr 1997

Keywords

  • SYSTEM ACTIVE COMPOUNDS

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