The neuronal mechanisms underlying locomotion termination

Emma Jean Ritson, Wen-Chang Li

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
26 Downloads (Pure)

Abstract

It is critical for animals to be able to stop locomotion according to their external and internal needs. Limited studies show there are dedicated neuronal pathways responding to either sensory inputs or commands from higher brain areas to inhibit the locomotor circuit and actively terminate locomotion. Such neuronal mechanisms are clearly demonstrated by the quick ending of ongoing locomotor rhythms following the activation of “stop” cells in the brainstem. In contrast, some activity-dependent mechanisms intrinsic to the locomotor neuronal network are responsible for the spontaneous ending of locomotor episodes. Known autonomous mechanisms involve the release/accumulative production of adenosine or the mediation of long-lasting hyperpolarisation by Na+ pumps following locomotion. We discuss some recent studies that have led to these findings.
Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalCurrent Opinion in Physiology
Volume8
Early online date7 Feb 2019
DOIs
Publication statusPublished - Apr 2019

Keywords

  • Locomotion
  • CPG
  • Brainstem
  • Stop cells

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