The Mnx homeobox class defined by HB9, MNR2 and amphioxus AmphiMnx.

David Ellard Keith Ferrier, N.M. Brooke, G. Panopoulou, P.W.H. Holland

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

The HB9 homeobox gene has been cloned from several vertebrates and is implicated in motor neuron differentiation. In the chick, a related gene, MNR2, acts upstream of HB9 in this process. Here we report an amphioxus homologue of these genes and show that it diverged before the gene duplication yielding HB9 and MNR2. AmphiMnx RNA is detected in two irregular punctate stripes along the developing neural tube, comparable to the distribution of 'dorsal compartment' motor neurons, and also in dorsal endoderm and posterior mesoderm. We propose a new homeobox class, Mnx, to include AmphiMnx, HB9, MNR2 and their Drosophila and echinoderm orthologues; we suggest that vertebrate HB9 is renamed Mnx1 and MNR2 be renamed Mnx2.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalDevelopment Genes and Evolution
Volume211
DOIs
Publication statusPublished - Feb 2001

Keywords

  • homeobox
  • motor neuron
  • amphioxus
  • gene duplication
  • MOTOR-NEURON IDENTITY
  • SACRAL AGENESIS
  • REGION
  • LOCUS
  • 7Q36

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