The mitochondrial compartment

David Logan

Research output: Contribution to journalArticlepeer-review

166 Citations (Scopus)

Abstract

Mitochondria are vital organelles that perform a variety of fundamental functions ranging from the synthesis of ATP through to being intimately involved in programmed cell death. Comprised of at least six compartments: outer membrane, inner boundary membrane, intermembrane space, cristal membranes, intracristal space, and matrix, mitochondria have a complex, dynamic internal structure. This internal dynamism is reflected in the pleomorphy and motility of mitochondria. Mitochondria contain their own DNA (mtDNA), encoding a small number of vital genes, but this role as a genetic vault is not compatible with the role of mitochondria in bioenergetics since electron transport results in the generation of reactive oxygen species (ROS) that induce lesions in the mtDNA. It is hypothesized that ROS shape the morphological organization of the higher plant cell mitochondrial population into a discontinuous whole, and that ROS are a selective pressure affecting the organization of the mitochondrial genome. This review describes how inter- and intra-mitochondrial compartmentalization underpins the biology of this complex organelle.

Original languageEnglish
Pages (from-to)1225-1243
Number of pages19
JournalJournal of Experimental Botany
Volume57
Issue number6
DOIs
Publication statusPublished - Mar 2006

Keywords

  • cytoskeleton
  • discontinuous whole
  • division
  • dynamics
  • fusion
  • mitochondria
  • mitochondrial genome
  • morphology
  • mutants
  • ultrastructure
  • DYNAMIN-RELATED GTPASE
  • TRANSLOCATION CONTACT SITES
  • PROGRAMMED DEATH PHENOMENA
  • HIGHER-PLANT MITOCHONDRIA
  • IMBIBED PEANUT COTYLEDONS
  • BOVINE HEART-MITOCHONDRIA
  • FIELD GEL-ELECTROPHORESIS
  • COATED VESICLE FORMATION
  • INDUCED CELL-DEATH
  • WD REPEAT PROTEIN

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