The mechanism of recoding in pro- and eukaryotes

Elizabeth S. Poole, Louise L. Major, Andrew G. Cridge, Warren P. Tate*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

This chapter contains sections titled: Introduction Maintaining Decoding Accuracy and the Reading Frame The Use of a Stop Signal for both Elongation and Termination of Protein Synthesis The Mechanism for Sec Incorporation at UGA Sites in Bacterial mRNAs The Gene Products The Mechanism of Sec Incorporation The Competition between Sec Incorporation and Canonical Decoding of UGA by RF2 Mechanism for Sec Incorporation at UGA Sites in Eukaryotic and Archaeal mRNAs The Gene Products The Mechanism of Sec Incorporation at Specific UGA Stop Codons Why does Recoding Occur at Stop Signals? The Stop Signal of Prokaryotic Genomes - Engineered for High Efficiency Decoding? The Stop Signal of Eukaryotic Genomes - Diversity Contributes to Recoding Readthrough of a Stop Signal: Decoding Stop as Sense Bypassing of a Stop Codon: 'Free-wheeling' on the mRNA Frameshifting Around Stop or Sense Codons Forward Frameshifting: the +1 Event Programed -1 Frameshifting: A Common Mechanism used by Many Viruses During Gene Expression Conclusion References

Original languageEnglish
Title of host publicationProtein Synthesis and Ribosome Structure
PublisherWiley
Pages397-428
Number of pages32
ISBN (Electronic)9783527603435
ISBN (Print)3527306382, 9783527306381
DOIs
Publication statusPublished - 20 Jan 2006

Keywords

  • Bypassing of a stop codon
  • Frameshifting around stop or sense codons
  • Protein synthesis
  • Readthrough of a stop signal
  • Recoding in pro- and eukaryotes
  • Ribosome structure
  • Sec incorporation at UGA sites in bacterial mRNAs
  • Sec incorporation in eukaryotic and archaeal mRNAs
  • Stop signal for both elongation and termination of protein synthesis

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