The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

Federica Gibellini; Terry K Smith

doi:10.1002/iub.337

The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

Federica Gibellini, Terry K Smith

Research output: Contribution to journal › Review article › peer-review

Abstract

The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. (C) 2010 IUBMB IUBMB Life, 62(6): 414-428, 2010

Original language	English
Pages (from-to)	414-428
Number of pages	15
Journal	IUBMB Life
Volume	62
Issue number	6
DOIs	https://doi.org/10.1002/iub.337
Publication status	Published - 3 Jun 2010

Keywords

Kennedy pathway
ethanolamine
choline
CDP-ethanolamine
CDP-choline
CTP-PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASE
EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS
CDP-ETHANOLAMINE PATHWAY
SACCHAROMYCES-CEREVISIAE
CHOLINE KINASE
RAT-LIVER
TRYPANOSOMA-BRUCEI
PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE
SPHINGOLIPID METABOLISM
MOLECULAR DISSECTION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/iub.337

Cite this

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title = "The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine",

abstract = "The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. (C) 2010 IUBMB IUBMB Life, 62(6): 414-428, 2010",

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author = "Federica Gibellini and Smith, {Terry K}",

year = "2010",

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doi = "10.1002/iub.337",

language = "English",

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TY - JOUR

T1 - The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

AU - Gibellini, Federica

AU - Smith, Terry K

PY - 2010/6/3

Y1 - 2010/6/3

N2 - The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. (C) 2010 IUBMB IUBMB Life, 62(6): 414-428, 2010

AB - The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. (C) 2010 IUBMB IUBMB Life, 62(6): 414-428, 2010

KW - Kennedy pathway

KW - ethanolamine

KW - choline

KW - CDP-ethanolamine

KW - CDP-choline

KW - CTP-PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASE

KW - EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS

KW - CDP-ETHANOLAMINE PATHWAY

KW - SACCHAROMYCES-CEREVISIAE

KW - CHOLINE KINASE

KW - RAT-LIVER

KW - TRYPANOSOMA-BRUCEI

KW - PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE

KW - SPHINGOLIPID METABOLISM

KW - MOLECULAR DISSECTION

UR - http://www.scopus.com/inward/record.url?scp=77953591461&partnerID=8YFLogxK

U2 - 10.1002/iub.337

DO - 10.1002/iub.337

M3 - Review article

SN - 1521-6543

VL - 62

SP - 414

EP - 428

JO - IUBMB Life

JF - IUBMB Life

IS - 6

ER -

The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

Abstract

Keywords

UN SDGs

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Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei

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The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei

Cite this