The junction-resolving enzymes

David M.J. Lilley; Malcolm F. White

doi:10.1038/35073057

The junction-resolving enzymes

David M.J. Lilley^*
, Malcolm F. White

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.

Original language	English
Pages (from-to)	433-443
Number of pages	11
Journal	Nature Reviews Molecular Cell Biology
Volume	2
Issue number	6
DOIs	https://doi.org/10.1038/35073057
Publication status	Published - 1 Jun 2001

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title = "The junction-resolving enzymes",

abstract = "Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.",

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AU - White, Malcolm F.

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N2 - Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.

AB - Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.

UR - https://www.scopus.com/pages/publications/0035379812

U2 - 10.1038/35073057

DO - 10.1038/35073057

M3 - Review article

C2 - 11389467

AN - SCOPUS:0035379812

SN - 1471-0072

VL - 2

SP - 433

EP - 443

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 6

ER -

The junction-resolving enzymes

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