The junction-resolving enzymes

David M.J. Lilley*, Malcolm F. White

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

132 Citations (Scopus)


Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.

Original languageEnglish
Pages (from-to)433-443
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number6
Publication statusPublished - 1 Jun 2001


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