The intracellular interactions of the L1-Cell Adhesion Molecule family

LR Herron; M Hill; F Davey; Francis James Gunn-Moore

doi:10.1042/BJ20082284

The intracellular interactions of the L1-Cell Adhesion Molecule family

LR Herron, M Hill, F Davey, Francis James Gunn-Moore

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The L1 family of CAMs (cell adhesion molecules) has long aroused the interest of researchers, but primarily the extracellular interactions of these proteins have been elucidated. More recently, attention has turned to the intracellular signalling potentiated by transmembrane proteins and the cytoplasmic proteins with which they can interact. The present review brings up to date the current body of published knowledge for the intracellular interactions of L1-CAM family proteins and the potential importance of these interactions for the mechanisms of L1-CAM action.

Original language	English
Pages (from-to)	519-531
Number of pages	13
Journal	Biochemical Journal
Volume	419
Issue number	3
DOIs	https://doi.org/10.1042/BJ20082284
Publication status	Published - 1 May 2009

Keywords

close homologue of L1 (CHL1)
L1
neurofascin
neuron-glia-related CAM (NrCAM)
protein-protein interaction
ANKYRIN-BINDING-ACTIVITY
ASPARTATE RECEPTOR COMPLEX
CLOSE HOMOLOG
CYTOPLASMIC DOMAIN
NEURITE OUTGROWTH
NERVOUS-SYSTEM
PROTEIN INTERACTIONS
ERM PROTEINS
GROWTH CONE
DEPENDENT PHOSPHORYLATION

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abstract = "The L1 family of CAMs (cell adhesion molecules) has long aroused the interest of researchers, but primarily the extracellular interactions of these proteins have been elucidated. More recently, attention has turned to the intracellular signalling potentiated by transmembrane proteins and the cytoplasmic proteins with which they can interact. The present review brings up to date the current body of published knowledge for the intracellular interactions of L1-CAM family proteins and the potential importance of these interactions for the mechanisms of L1-CAM action.",

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AU - Hill, M

AU - Davey, F

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JO - Biochemical Journal

JF - Biochemical Journal

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The intracellular interactions of the L1-Cell Adhesion Molecule family

Abstract

Keywords

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