The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

Lindsay B. Tulloch; Jacqueline Howie; Krzysztof J. Wypijewski; Catherine R. Wilson; William G. Bernard; Michael J. Shattock; William Fuller

doi:10.1074/jbc.M111.282145

The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

Lindsay B. Tulloch, Jacqueline Howie, Krzysztof J. Wypijewski, Catherine R. Wilson, William G. Bernard, Michael J. Shattock, William Fuller^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.

Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.

Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.

Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

Original language	English
Pages (from-to)	36020-36031
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	286
Issue number	41
DOIs	https://doi.org/10.1074/jbc.M111.282145
Publication status	Published - 14 Oct 2011

Keywords

MYOCYTES
FXYD PROTEINS
PLASMA-MEMBRANE
PROTEIN-KINASE-C
CARDIAC NA/K ATPASE
PHOSPHORYLATION
POTASSIUM PUMP
NA+-K+-ATPASE
SITES
CRYSTAL-STRUCTURE

Access to Document

10.1074/jbc.M111.282145

Cite this

@article{d1c932d2598e47e99ce646ea79f22a89,

title = "The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation",

abstract = "Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.",

keywords = "MYOCYTES, FXYD PROTEINS, PLASMA-MEMBRANE, PROTEIN-KINASE-C, CARDIAC NA/K ATPASE, PHOSPHORYLATION, POTASSIUM PUMP, NA+-K+-ATPASE, SITES, CRYSTAL-STRUCTURE",

author = "Tulloch, \{Lindsay B.\} and Jacqueline Howie and Wypijewski, \{Krzysztof J.\} and Wilson, \{Catherine R.\} and Bernard, \{William G.\} and Shattock, \{Michael J.\} and William Fuller",

year = "2011",

month = oct,

day = "14",

doi = "10.1074/jbc.M111.282145",

language = "English",

volume = "286",

pages = "36020--36031",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "41",

}

TY - JOUR

T1 - The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

AU - Tulloch, Lindsay B.

AU - Howie, Jacqueline

AU - Wypijewski, Krzysztof J.

AU - Wilson, Catherine R.

AU - Bernard, William G.

AU - Shattock, Michael J.

AU - Fuller, William

PY - 2011/10/14

Y1 - 2011/10/14

N2 - Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

AB - Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

KW - MYOCYTES

KW - FXYD PROTEINS

KW - PLASMA-MEMBRANE

KW - PROTEIN-KINASE-C

KW - CARDIAC NA/K ATPASE

KW - PHOSPHORYLATION

KW - POTASSIUM PUMP

KW - NA+-K+-ATPASE

KW - SITES

KW - CRYSTAL-STRUCTURE

UR - https://www.scopus.com/pages/publications/80053897407

U2 - 10.1074/jbc.M111.282145

DO - 10.1074/jbc.M111.282145

M3 - Article

SN - 0021-9258

VL - 286

SP - 36020

EP - 36031

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 41

ER -

The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this