Abstract
Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.
Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.
Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.
Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.
Original language | English |
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Pages (from-to) | 36020-36031 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 286 |
Issue number | 41 |
DOIs | |
Publication status | Published - 14 Oct 2011 |
Keywords
- MYOCYTES
- FXYD PROTEINS
- PLASMA-MEMBRANE
- PROTEIN-KINASE-C
- CARDIAC NA/K ATPASE
- PHOSPHORYLATION
- POTASSIUM PUMP
- NA+-K+-ATPASE
- SITES
- CRYSTAL-STRUCTURE