The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation

Lindsay B. Tulloch, Jacqueline Howie, Krzysztof J. Wypijewski, Catherine R. Wilson, William G. Bernard, Michael J. Shattock, William Fuller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.

Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.

Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.

Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

Original languageEnglish
Pages (from-to)36020-36031
Number of pages12
JournalJournal of Biological Chemistry
Volume286
Issue number41
DOIs
Publication statusPublished - 14 Oct 2011

Keywords

  • MYOCYTES
  • FXYD PROTEINS
  • PLASMA-MEMBRANE
  • PROTEIN-KINASE-C
  • CARDIAC NA/K ATPASE
  • PHOSPHORYLATION
  • POTASSIUM PUMP
  • NA+-K+-ATPASE
  • SITES
  • CRYSTAL-STRUCTURE

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