The importance of DNA methylation in prostate cancer development

Charles E. Massie; Ian G. Mills; Andy G. Lynch

doi:10.1016/j.jsbmb.2016.04.009

The importance of DNA methylation in prostate cancer development

Charles E. Massie, Ian G. Mills, Andy G. Lynch

Research output: Contribution to journal › Review article › peer-review

Abstract

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets.
We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by androgen receptor, with a specific discussion of the mitochondria and their associations with DNA methylation.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	The Journal of Steroid Biochemistry and Molecular Biology
Volume	166
Early online date	24 Apr 2016
DOIs	https://doi.org/10.1016/j.jsbmb.2016.04.009
Publication status	Published - Feb 2017

Keywords

Prostate cancer
Epigenetic
Methylation
Biomarkers
Metabolism
Mitochondria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jsbmb.2016.04.009Licence: CC BY

Lynch_2017_JSBMB_DNAmethylation_CC
© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 888 KBLicence: CC BY

Cite this

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title = "The importance of DNA methylation in prostate cancer development",

abstract = "After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets.We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by androgen receptor, with a specific discussion of the mitochondria and their associations with DNA methylation.",

keywords = "Prostate cancer, Epigenetic, Methylation, Biomarkers, Metabolism, Mitochondria",

author = "Massie, {Charles E.} and Mills, {Ian G.} and Lynch, {Andy G.}",

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language = "English",

volume = "166",

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journal = "The Journal of Steroid Biochemistry and Molecular Biology",

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T1 - The importance of DNA methylation in prostate cancer development

AU - Massie, Charles E.

AU - Mills, Ian G.

AU - Lynch, Andy G.

PY - 2017/2

Y1 - 2017/2

N2 - After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets.We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by androgen receptor, with a specific discussion of the mitochondria and their associations with DNA methylation.

AB - After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets.We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by androgen receptor, with a specific discussion of the mitochondria and their associations with DNA methylation.

KW - Prostate cancer

KW - Epigenetic

KW - Methylation

KW - Biomarkers

KW - Metabolism

KW - Mitochondria

U2 - 10.1016/j.jsbmb.2016.04.009

DO - 10.1016/j.jsbmb.2016.04.009

M3 - Review article

SN - 0960-0760

VL - 166

SP - 1

EP - 15

JO - The Journal of Steroid Biochemistry and Molecular Biology

JF - The Journal of Steroid Biochemistry and Molecular Biology

ER -

The importance of DNA methylation in prostate cancer development

Abstract

Keywords

UN SDGs

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