The importance of DNA methylation in prostate cancer development

Charles E. Massie, Ian G. Mills, Andy G. Lynch

Research output: Contribution to journalReview articlepeer-review

71 Citations (Scopus)

Abstract

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets.
We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by androgen receptor, with a specific discussion of the mitochondria and their associations with DNA methylation.
Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalThe Journal of Steroid Biochemistry and Molecular Biology
Volume166
Early online date24 Apr 2016
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Prostate cancer
  • Epigenetic
  • Methylation
  • Biomarkers
  • Metabolism
  • Mitochondria

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