The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

Han Xiao; Marian Jane Killip; Peter Staeheli; Richard Edward Randall; David Jackson

doi:10.1128/JVI.02220-13

The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

Han Xiao, Marian Jane Killip, Peter Staeheli, Richard Edward Randall, David Jackson

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Abstract

The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.

Original language	English
Pages (from-to)	13053-13058
Journal	Journal of Virology
Volume	87
Issue number	23
Early online date	18 Sept 2013
DOIs	https://doi.org/10.1128/JVI.02220-13
Publication status	Published - Dec 2013

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10.1128/JVI.02220-13

JVirol-2013-Xiao-13053-8
Copyright © 2013 Xiao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
Final published version, 1.31 MB

The Interaction of paramyxoviruses: The interaction of paramyxoviruses with the interferon system
Randall, R. E. (PI)
The Wellcome Trust
1/04/09 → 31/03/14
Project: Standard

Cite this

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title = "The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm",

abstract = "The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.",

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AU - Jackson, David

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AB - The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.

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The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

Abstract

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The Interaction of paramyxoviruses: The interaction of paramyxoviruses with the interferon system

Cite this