The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

Han Xiao, Marian Jane Killip, Peter Staeheli, Richard Edward Randall, David Jackson

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)
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Abstract

The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
Original languageEnglish
Pages (from-to)13053-13058
JournalJournal of Virology
Volume87
Issue number23
Early online date18 Sept 2013
DOIs
Publication statusPublished - Dec 2013

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