Projects per year
Abstract
A mechanistic study of the gold-catalysed protodecarboxylation is described. Each reaction step has been investigated experimentally and computationally. More specifically, the activation parameters for the decarboxylation step have been determined through kinetic studies. Further experimental studies on the hydrolysis of the arylgold intermediate have revealed that the protodeauration can become competitive with the decarboxylation process at high conversions. This switch in rate-limiting step has been shown to be pKa-dependent. These studies have been supported by DFT calculations and permit a better understanding of which prevalent features of the reaction mechanism account for the decarboxylation process.
Original language | English |
---|---|
Pages (from-to) | 3399-3408 |
Journal | Chemistry - A European Journal |
Volume | 21 |
Issue number | 8 |
Early online date | 7 Jan 2015 |
DOIs | |
Publication status | Published - 16 Feb 2015 |
Keywords
- Decarboxylation
- Gold
- Mechanism
- N-heterocycle carbenes
- Protodeauration
Fingerprint
Dive into the research topics of 'The gold(I)-catalysed protodecarboxylation mechanism'. Together they form a unique fingerprint.Projects
- 1 Finished
-
FUNCAT: EU FP7 ERC Advanced Grant - FUNCAT - Fundamental Studies in Organometallic Chemistry and Homogeneous Catalysis
Nolan, S. P. (PI)
1/01/09 → 31/12/14
Project: Standard