The G5 domain: a potential N-acetylglucosamine recognition domain involved in biofilm formation

A Bateman*, MTG Holden, C Yeats

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

Biofilms are complex microbial communities found at surfaces that are often associated with extracellular polysaccharides. Biofilm formation is a complex process that is being understood at the molecular level only recently. We have identified a novel domain that we call the G5 domain (named after its conserved glycine residues), which is found in a variety of enzymes such as Streptococcal IgA peptidases and various glycosyl hydrolases in bacteria. The G5 domain is found in the Accumulation Associated Protein (AAP), which is an important component in biofilm formation in Staphylococcus aureus. A common feature of the proteins containing G5 domains is N-acetylglucosamine binding, and we attribute this function to the G5 domain.

Original languageEnglish
Pages (from-to)1301-1303
Number of pages3
JournalBioinformatics
Volume21
Issue number8
DOIs
Publication statusPublished - 15 Apr 2005

Keywords

  • RESISTANT STAPHYLOCOCCUS-AUREUS
  • PROTEIN FAMILIES DATABASE
  • EXPRESSION
  • CLONING
  • GENE

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