The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R. Prescott, Oforiwa A. Gorleku, Luke H. Chamberlain

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalMolecular Membrane Biology
Volume26
Issue number1-2
DOIs
Publication statusPublished - 2009

Keywords

  • Palmitoylation
  • protein sorting
  • membrane microdomains
  • lipid rafts
  • protein trafficking
  • CYSTEINE-STRING PROTEIN
  • GPI-ANCHORED PROTEINS
  • SRC-FAMILY KINASE
  • PLASMA-MEMBRANE
  • LIPID RAFTS
  • MODEL MEMBRANES
  • CELL-MEMBRANES
  • H-RAS
  • SUBCELLULAR-LOCALIZATION
  • SACCHAROMYCES-CEREVISIAE

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