The evolution and suppression of male suicide under paternal genome elimination

Laura Ross, David Michael Shuker, Ido Pen

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Different genetic systems can be both the cause and the consequence of genetic conflict over the transmission of genes, obscuring their evolutionary origin. For instance, with paternal genome elimination (PGE), found in some insects and mites, both sexes develop from fertilized eggs, but in males the paternally derived chromosomes are either lost (embryonic PGE) or deactivated (germline PGE) during embryogenesis and not transmitted to the next generation. Evolution of germline PGE requires two transitions: (1) elimination of the paternal genome during spermatogenesis; (2) deactivation of the paternal genome early in development. Hypotheses for the evolution of PGE have mainly focused on the first transition. However, maternal genes seem to be responsible for the deactivation and here we investigate if maternal suppression could have evolved in response to paternally expressed male suicide genes. We show that sibling competition can cause such genes to spread quickly and that inbreeding is necessary to prevent fixation of male suicide, and subsequent population extinction. Once male-suicide has evolved, maternally expressed suppressor genes can invade in the population. Our results highlight the rich opportunity for genetic conflict in asymmetric genetic systems and the counterintuitive phenotypes that can evolve as a result.

Original languageEnglish
Pages (from-to)554-563
Number of pages10
JournalEvolution
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Genetic system
  • genomic conflict
  • male-killing
  • paternal genome elimination
  • scale insect
  • UNUSUAL CHROMOSOMAL SYSTEMS
  • EXTRAORDINARY SEX-RATIOS
  • SCALE INSECTS
  • PLANOCOCCUS-CITRI
  • GENETIC SYSTEMS
  • HETEROCHROMATIC CHROMOSOMES
  • SCIARID FLIES
  • MALE HAPLOIDY
  • MEALY BUG
  • CONFLICT

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