The evolution and mechanisms of nucleotide excision repair proteins

Christophe Rouillon, Malcolm F. White

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

Nucleotide excision repair (NER) pathways remove a wide variety of bulky and helix-distorting lesions from DNA, and involve the coordinated action of damage detection, helicase and nuclease proteins. Most archaeal genomes encode eucaryal-type NER proteins, including the helicases XPB and XPD and nuclease XPF. These have been a valuable resource, yielding important mechanistic and structural insights relevant to human health. However, the nature of archaeal NER remains very uncertain. Here we review recent studies of archaeal NER proteins relevant to both eucaryal and archaeal NER systems and the evolution of repair pathways. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalResearch in Microbiology
Volume162
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Archaea
  • XPB
  • XPD
  • XPF
  • Helicase
  • Nuclease
  • DNA-BINDING-PROTEIN
  • XERODERMA-PIGMENTOSUM
  • ESCHERICHIA-COLI
  • XPD HELICASE
  • SULFOLOBUS-SOLFATARICUS
  • CRYSTAL-STRUCTURE
  • ENDONUCLEASE
  • RECOGNITION
  • NUCLEASE
  • DAMAGE

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