The evoked potentials score improves the identification of benign MS without cognitive impairment

N. Margaritella; L. Mendozzi; F. Tronci; E. Colicino; M. Garegnani; R. Nemni; E. Gilardi; L. Pugnetti

doi:10.1111/ene.12071

The evoked potentials score improves the identification of benign MS without cognitive impairment

N. Margaritella, L. Mendozzi, F. Tronci, E. Colicino, M. Garegnani, R. Nemni, E. Gilardi, L. Pugnetti^*

^*Corresponding author for this work

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Abstract

Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI.

Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods.

Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%).

Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

Original language	English
Pages (from-to)	1423-1425
Number of pages	3
Journal	European Journal of Neurology
Volume	20
Issue number	10
Early online date	7 Jan 2013
DOIs	https://doi.org/10.1111/ene.12071
Publication status	Published - Oct 2013

Keywords

Benign MS
Cognition
Evoked potentials
Evoked potentials score
Multiple sclerosis
Resampling methods

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10.1111/ene.12071

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title = "The evoked potentials score improves the identification of benign MS without cognitive impairment",

abstract = "Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.",

keywords = "Benign MS, Cognition, Evoked potentials, Evoked potentials score, Multiple sclerosis, Resampling methods",

author = "N. Margaritella and L. Mendozzi and F. Tronci and E. Colicino and M. Garegnani and R. Nemni and E. Gilardi and L. Pugnetti",

note = "This study was supported by a grant of the Italian Ministry of Health, Ricerca Corrente funding pro-gram 2011–2012 (RC2011).",

year = "2013",

month = oct,

doi = "10.1111/ene.12071",

language = "English",

volume = "20",

pages = "1423--1425",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Academic Press/Elsevier ",

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TY - JOUR

T1 - The evoked potentials score improves the identification of benign MS without cognitive impairment

AU - Margaritella, N.

AU - Mendozzi, L.

AU - Tronci, F.

AU - Colicino, E.

AU - Garegnani, M.

AU - Nemni, R.

AU - Gilardi, E.

AU - Pugnetti, L.

N1 - This study was supported by a grant of the Italian Ministry of Health, Ricerca Corrente funding pro-gram 2011–2012 (RC2011).

PY - 2013/10

Y1 - 2013/10

N2 - Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

AB - Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

KW - Benign MS

KW - Cognition

KW - Evoked potentials

KW - Evoked potentials score

KW - Multiple sclerosis

KW - Resampling methods

U2 - 10.1111/ene.12071

DO - 10.1111/ene.12071

M3 - Article

C2 - 23293907

AN - SCOPUS:84883749060

SN - 1351-5101

VL - 20

SP - 1423

EP - 1425

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 10

ER -

The evoked potentials score improves the identification of benign MS without cognitive impairment

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Keywords

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