The evoked potentials score improves the identification of benign MS without cognitive impairment

N. Margaritella, L. Mendozzi, F. Tronci, E. Colicino, M. Garegnani, R. Nemni, E. Gilardi, L. Pugnetti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. 

Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. 

Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). 

Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

Original languageEnglish
Pages (from-to)1423-1425
Number of pages3
JournalEuropean Journal of Neurology
Volume20
Issue number10
Early online date7 Jan 2013
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Benign MS
  • Cognition
  • Evoked potentials
  • Evoked potentials score
  • Multiple sclerosis
  • Resampling methods

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