The EP-score to assess treatment efficacy in RRMS patients: a preliminary study

Nicolò Margaritella, Laura Mendozzi, Massimo Garegnani, Raffaello Nemni, Elisabetta Gilardi, Luigi Pugnetti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


AIM OF THE STUDY: The aim of this retrospective study was to preliminarily assess whether the EP-score, a summary score derived from multimodal evoked potentials tests, might be used as a measure of treatment efficacy in multiple sclerosis (MS).

MATERIALS AND METHODS: A sample of 56 relapsing remitting MS (RRMS) patients who at diagnosis started treatment with interferon β (INFβ, n = 19), glatiramer acetate (GA, n = 15) or refused any chronic treatment were assessed at baseline (before treatment) and at a median of 1.7 and 3.6 years thereafter. Outcome variables were Expanded Disability Status Scale (EDSS), EP-Score, visual evoked potentials (VEP) and somatosensory evoked potentials (SEP) scores measured as differences between baseline and follow-ups. Statistical differences between groups and follow-ups were assessed using non-parametric analyses.

RESULTS: Treatment effects were not significant for EDSS both at the first and at the second follow-up, while a trend toward significance was observed in the EP-score only in the first follow-up (p = 0.07). Post-hoc analysis showed a greater decrease in median VEP-score for the IFNβ group compared to the GA and DF groups at both the first and second follow-ups.

CONCLUSIONS: We found no evidence that either INFβ or GA significantly improved disability in RRMS patients. Using the EP-score as an outcome measure, we found that it was improved at both follow-ups in the INFβ group mainly due to a decrease in the VEP-score. This finding supports the proposal to include the EP-score as an additional outcome variable in future studies of treatment efficacy in MS.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalThe International Journal of Neuroscience
Issue number1
Early online date8 May 2014
Publication statusPublished - Jan 2015


  • Adult
  • Disability Evaluation
  • Disabled Persons
  • Electroencephalography
  • Evoked Potentials, Somatosensory/physiology
  • Evoked Potentials, Visual/physiology
  • Female
  • Follow-Up Studies
  • Glatiramer Acetate
  • Humans
  • Immunologic Factors/therapeutic use
  • Interferon-beta/therapeutic use
  • Male
  • Multiple Sclerosis, Relapsing-Remitting/diagnosis
  • Outcome Assessment, Health Care
  • Peptides/therapeutic use
  • Retrospective Studies
  • Young Adult


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