The enzymatic resolution of an _- fluoroamide by an acylase

JW Banks, David O'Hagan

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The acylase from Aspergillus melleus was able to hydrolyse the amide bond of (S)-phenylalanine-N-2-(R,S)-fluoropropionamide and discriminate the diastereoisomers such that the (S,S)-diastereoisomer was hydrolysed by an order of magnitude faster than the (S,R)diasteroisomer. The origin of the kinetic discrimination is attributed to both binding and kinetic effects. (C) 2000 Elsevier Science S.A. All rights reserved.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalJournal of Fluorine Chemistry
Volume102
Publication statusPublished - Mar 2000

Keywords

  • F-19-NMR
  • acylase
  • Aspergillus melleus
  • alpha-fluoroamide
  • enzyme resolution
  • PYRIDINE
  • FLUORINE

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