The diagnosis of streptococcus pneumoniae infections

S. H. Gillespie*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The diagnosis of infection by Streptococcus pneumoniae is an important task for microbiology laboratories in view of its prevalence, high mortality and the recent spread of penicillin resistance. ELISA, CIE, LA and CoAG methods have been described for the detection of capsular polysaccharide (CPS) and C-polysaccharide (PnC) in sputum and all have similar sensitivity. Antigen detection in serum has a low diagnostic yield unless bacteraemia is present. Detection of antigen in urine is more sensitive but the need to concentrate the specimen has limited the application of this technique in routine practice. The polymerase chain reaction for an autolysin gene shows promise for diagnosis in blood and sputum.

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalReviews in Medical Microbiology
Issue number4
Publication statusPublished - 1 Jan 1994


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