The diagnosis of streptococcus pneumoniae infections

S. H. Gillespie

doi:10.1097/00013542-199410000-00002

The diagnosis of streptococcus pneumoniae infections

S. H. Gillespie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The diagnosis of infection by Streptococcus pneumoniae is an important task for microbiology laboratories in view of its prevalence, high mortality and the recent spread of penicillin resistance. ELISA, CIE, LA and CoAG methods have been described for the detection of capsular polysaccharide (CPS) and C-polysaccharide (PnC) in sputum and all have similar sensitivity. Antigen detection in serum has a low diagnostic yield unless bacteraemia is present. Detection of antigen in urine is more sensitive but the need to concentrate the specimen has limited the application of this technique in routine practice. The polymerase chain reaction for an autolysin gene shows promise for diagnosis in blood and sputum.

Original language	English
Pages (from-to)	224-232
Number of pages	9
Journal	Reviews in Medical Microbiology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1097/00013542-199410000-00002
Publication status	Published - 1 Jan 1994

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AB - The diagnosis of infection by Streptococcus pneumoniae is an important task for microbiology laboratories in view of its prevalence, high mortality and the recent spread of penicillin resistance. ELISA, CIE, LA and CoAG methods have been described for the detection of capsular polysaccharide (CPS) and C-polysaccharide (PnC) in sputum and all have similar sensitivity. Antigen detection in serum has a low diagnostic yield unless bacteraemia is present. Detection of antigen in urine is more sensitive but the need to concentrate the specimen has limited the application of this technique in routine practice. The polymerase chain reaction for an autolysin gene shows promise for diagnosis in blood and sputum.

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The diagnosis of streptococcus pneumoniae infections

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