The development of palladium catalysts for C-C and C-heteroatom bond forming reactions of aryl chloride substrates

R B Bedford, C S J Cazin, D Holder

Research output: Contribution to journalReview articlepeer-review

593 Citations (Scopus)

Abstract

The design and application of new homogeneous palladium catalysts for the formation of C-C and C-heteroatom bonds from aryl chloride substrates is reviewed. Much of the work performed in this area has focused on the synthesis of bulky, electron-rich phosphines and, more recently, carbenes that increase the electron density on the palladium centre(s) sufficiently to facilitate oxidative addition of the strong C-Cl bond. However, there has increasingly been an interest in the development of alternative palladium sources that improve activity when used in association with these ligands, for instance, palladacyclic complexes have played a particular role in this regard. (C) 2004 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)2283-2321
Number of pages39
JournalCoordination Chemistry Reviews
Volume248
Issue number21-24
DOIs
Publication statusPublished - Dec 2004

Keywords

  • palladium
  • catalyst
  • heteroatom
  • C-C bond forming
  • coupling
  • CROSS-COUPLING REACTIONS
  • N-HETEROCYCLIC CARBENES
  • HIGHLY-ACTIVE CATALYSTS
  • HECK-TYPE REACTIONS
  • ARYLBORONIC ACIDS
  • ROOM-TEMPERATURE
  • SUZUKI REACTION
  • EFFICIENT CATALYSTS
  • GENERAL-METHOD
  • O BOND

Fingerprint

Dive into the research topics of 'The development of palladium catalysts for C-C and C-heteroatom bond forming reactions of aryl chloride substrates'. Together they form a unique fingerprint.

Cite this