The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction

Jesko Alexander Johannes Gunter Koehnke; Andrew Frank Bent; David Zollman; Kieran Smith; Wael E.  Houssen; Xiaofeng Zhu; Greg Mann; Tomas Lebl; Richard Scharff; Sally Lorna Shirran; Catherine Helen Botting; Marcel Jaspers; Uli Schwarz-Linek; Jim Naismith

doi:10.1002/anie.201306302

The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction

Jesko Alexander Johannes Gunter Koehnke, Andrew Frank Bent, David Zollman, Kieran Smith, Wael E. Houssen, Xiaofeng Zhu, Greg Mann, Tomas Lebl, Richard Scharff, Sally Lorna Shirran, Catherine Helen Botting, Marcel Jaspers, Uli Schwarz-Linek, Jim Naismith

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	13991-13996
Number of pages	7
Journal	Angewandte Chemie International Edition
Volume	52
Issue number	52
Early online date	8 Nov 2013
DOIs	https://doi.org/10.1002/anie.201306302
Publication status	Published - Dec 2013

Keywords

Adenylation
Cyanobactins
Heterocyclase
Ribosomal peptide pathways

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10.1002/anie.201306302

Koehnke-AngewandteChemie201306302
© 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.35 MB

Exploring the mechanism: Exploring the mechanism and scope of the enzymatic formation of five membered ring
Naismith, J. (PI), Botting, C. H. (CoI), Koehnke, J. A. J. G. (CoI) & Schwarz-Linek, U. (CoI)
BBSRC
1/10/13 → 30/09/17
Project: Standard

Cite this

Koehnke, J. A. J. G., Bent, A. F., Zollman, D., Smith, K., Houssen, W. E., Zhu, X., Mann, G., Lebl, T., Scharff, R., Shirran, S. L., Botting, C. H., Jaspers, M., Schwarz-Linek, U., & Naismith, J. (2013). The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction. Angewandte Chemie International Edition, 52(52), 13991-13996. https://doi.org/10.1002/anie.201306302

@article{8c7fc9906d4b477d88679a596ea7a62a,

title = "The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction",

keywords = "Adenylation, Cyanobactins, Heterocyclase, Ribosomal peptide pathways",

author = "Koehnke, {Jesko Alexander Johannes Gunter} and Bent, {Andrew Frank} and David Zollman and Kieran Smith and Houssen, {Wael E.} and Xiaofeng Zhu and Greg Mann and Tomas Lebl and Richard Scharff and Shirran, {Sally Lorna} and Botting, {Catherine Helen} and Marcel Jaspers and Uli Schwarz-Linek and Jim Naismith",

note = "This work was funded by the Leverhulme Trust (RPG-2012–504), BBSRC (BB/K015508/1) and the University of St Andrews infrastructure is supported by a Wellcome Trust Capital Award (086036).",

year = "2013",

month = dec,

doi = "10.1002/anie.201306302",

language = "English",

volume = "52",

pages = "13991--13996",

journal = "Angewandte Chemie International Edition",

issn = "1521-3773",

publisher = "John Wiley & Sons, Ltd",

number = "52",

}

Koehnke, JAJG, Bent, AF, Zollman, D, Smith, K, Houssen, WE, Zhu, X, Mann, G, Lebl, T, Scharff, R, Shirran, SL, Botting, CH, Jaspers, M, Schwarz-Linek, U & Naismith, J 2013, 'The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction', Angewandte Chemie International Edition, vol. 52, no. 52, pp. 13991-13996. https://doi.org/10.1002/anie.201306302

TY - JOUR

T1 - The cyanobactin heterocyclase enzyme

T2 - A processive adenylase that operates with a defined order of reaction

AU - Koehnke, Jesko Alexander Johannes Gunter

AU - Bent, Andrew Frank

AU - Zollman, David

AU - Smith, Kieran

AU - Houssen, Wael E.

AU - Zhu, Xiaofeng

AU - Mann, Greg

AU - Lebl, Tomas

AU - Scharff, Richard

AU - Shirran, Sally Lorna

AU - Botting, Catherine Helen

AU - Jaspers, Marcel

AU - Schwarz-Linek, Uli

AU - Naismith, Jim

N1 - This work was funded by the Leverhulme Trust (RPG-2012–504), BBSRC (BB/K015508/1) and the University of St Andrews infrastructure is supported by a Wellcome Trust Capital Award (086036).

PY - 2013/12

Y1 - 2013/12

KW - Adenylation

KW - Cyanobactins

KW - Heterocyclase

KW - Ribosomal peptide pathways

U2 - 10.1002/anie.201306302

DO - 10.1002/anie.201306302

M3 - Article

SN - 1521-3773

VL - 52

SP - 13991

EP - 13996

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 52

ER -

The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction

Keywords

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Projects

Exploring the mechanism: Exploring the mechanism and scope of the enzymatic formation of five membered ring

Cite this