The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications

S G  Davies; A D  Smith; P D  Price

doi:10.1016/j.tetasy.2005.08.006

The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications

S G Davies, A D Smith, P D Price

Research output: Contribution to journal › Review article › peer-review

Abstract

This review delineates the scope and limitations of the conjugate addition of homochiral lithium amides to act as homochiral ammonia equivalents for the asymmetric synthesis of a range of beta-amino carboxylic acid derivatives and its widespread applications in synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2833-2891
Number of pages	59
Journal	Tetrahedron: Asymmetry
Volume	16
Issue number	17
DOIs	https://doi.org/10.1016/j.tetasy.2005.08.006
Publication status	Published - 5 Sept 2005

Keywords

BETA-AMINO ACIDS
PARALLEL KINETIC RESOLUTION
NONPEPTIDE ALPHA(V)BETA(3) ANTAGONISTS
MEISENHEIMER REARRANGEMENT PROTOCOL
EXPEDITIOUS ASYMMETRIC-SYNTHESIS
RING CLOSING METATHESIS
CHIRAL BUILDING-BLOCK
ALPHA-HYDROXY ACIDS
IRON ACYL COMPLEXES
ENANTIOSELECTIVE SYNTHESIS

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10.1016/j.tetasy.2005.08.006

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title = "The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications",

abstract = "This review delineates the scope and limitations of the conjugate addition of homochiral lithium amides to act as homochiral ammonia equivalents for the asymmetric synthesis of a range of beta-amino carboxylic acid derivatives and its widespread applications in synthesis. (c) 2005 Elsevier Ltd. All rights reserved.",

keywords = "BETA-AMINO ACIDS, PARALLEL KINETIC RESOLUTION, NONPEPTIDE ALPHA(V)BETA(3) ANTAGONISTS, MEISENHEIMER REARRANGEMENT PROTOCOL, EXPEDITIOUS ASYMMETRIC-SYNTHESIS, RING CLOSING METATHESIS, CHIRAL BUILDING-BLOCK, ALPHA-HYDROXY ACIDS, IRON ACYL COMPLEXES, ENANTIOSELECTIVE SYNTHESIS",

author = "Davies, {S G} and Smith, {A D} and Price, {P D}",

year = "2005",

month = sep,

day = "5",

doi = "10.1016/j.tetasy.2005.08.006",

language = "English",

volume = "16",

pages = "2833--2891",

journal = "Tetrahedron: Asymmetry",

issn = "0957-4166",

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number = "17",

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TY - JOUR

T1 - The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications

AU - Davies, S G

AU - Smith, A D

AU - Price, P D

PY - 2005/9/5

Y1 - 2005/9/5

N2 - This review delineates the scope and limitations of the conjugate addition of homochiral lithium amides to act as homochiral ammonia equivalents for the asymmetric synthesis of a range of beta-amino carboxylic acid derivatives and its widespread applications in synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

AB - This review delineates the scope and limitations of the conjugate addition of homochiral lithium amides to act as homochiral ammonia equivalents for the asymmetric synthesis of a range of beta-amino carboxylic acid derivatives and its widespread applications in synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

KW - BETA-AMINO ACIDS

KW - PARALLEL KINETIC RESOLUTION

KW - NONPEPTIDE ALPHA(V)BETA(3) ANTAGONISTS

KW - MEISENHEIMER REARRANGEMENT PROTOCOL

KW - EXPEDITIOUS ASYMMETRIC-SYNTHESIS

KW - RING CLOSING METATHESIS

KW - CHIRAL BUILDING-BLOCK

KW - ALPHA-HYDROXY ACIDS

KW - IRON ACYL COMPLEXES

KW - ENANTIOSELECTIVE SYNTHESIS

U2 - 10.1016/j.tetasy.2005.08.006

DO - 10.1016/j.tetasy.2005.08.006

M3 - Review article

SN - 0957-4166

VL - 16

SP - 2833

EP - 2891

JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

IS - 17

ER -

The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications

Abstract

Keywords

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