The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications

S G Davies, A D Smith, P D Price

Research output: Contribution to journalReview articlepeer-review

261 Citations (Scopus)

Abstract

This review delineates the scope and limitations of the conjugate addition of homochiral lithium amides to act as homochiral ammonia equivalents for the asymmetric synthesis of a range of beta-amino carboxylic acid derivatives and its widespread applications in synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2833-2891
Number of pages59
JournalTetrahedron: Asymmetry
Volume16
Issue number17
DOIs
Publication statusPublished - 5 Sept 2005

Keywords

  • BETA-AMINO ACIDS
  • PARALLEL KINETIC RESOLUTION
  • NONPEPTIDE ALPHA(V)BETA(3) ANTAGONISTS
  • MEISENHEIMER REARRANGEMENT PROTOCOL
  • EXPEDITIOUS ASYMMETRIC-SYNTHESIS
  • RING CLOSING METATHESIS
  • CHIRAL BUILDING-BLOCK
  • ALPHA-HYDROXY ACIDS
  • IRON ACYL COMPLEXES
  • ENANTIOSELECTIVE SYNTHESIS

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