The common marmoset genome provides insight into primate biology and evolution

The Marmoset Genome Sequencing and Analysis Consortium

doi:10.1038/ng.3042

The common marmoset genome provides insight into primate biology and evolution

The Marmoset Genome Sequencing and Analysis Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application.

Original language	English
Pages (from-to)	850-857
Number of pages	8
Journal	Nature Genetics
Volume	46
Issue number	8
Early online date	20 Jul 2014
DOIs	https://doi.org/10.1038/ng.3042
Publication status	Published - Aug 2014

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Final published version, 688 KBLicence: CC BY-NC-SA

Carolin Kosiol
- ck202st-andrews.acuk
Person: Academic

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The common marmoset genome provides insight into primate biology and evolution

Abstract

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Carolin Kosiol

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