The Carnitine Acyltransferases and Their Role in Modulating Acyl-CoA Pools

Rona R. Ramsay*, Arduino Arduini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

The role of carnitine via the action of carnitine acyltransferase in buffering CoA availability in the mitochondrial matrix is well known. There is now sufficient evidence to extend this to a general role. Carnitine can buffer the acylation state of the CoA pool for any type of acyl group that is a substrate for the carnitine acyltransferase family of enzymes. Specific carnitine acyltransferases in each organelle or membrane can modulate the reserves of free CoA and acyl-CoA in ways specific to the local metabolic demands. The use of inhibitors of carnitine acyltransferases in complex systems and in vivo now permits exploration of the consequences of this role.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume302
Issue number2
DOIs
Publication statusPublished - 1 Jan 1993

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