TY - UNPB
T1 - The biology of aging in a social world
T2 - insights from free-ranging rhesus macaque
AU - Newman, Laura E.
AU - Testard, Camille
AU - DeCasien, Alex R.
AU - Chiou, Kenneth L.
AU - Watowich, Marina M.
AU - Janiak, Mareike C.
AU - Pavez-Fox, Melissa A.
AU - Sanchez Rosado, Mitchell R.
AU - Cooper, Eve B.
AU - Costa, Christina E.
AU - Petersen, Rachel M.
AU - Montague, Michael J.
AU - Platt, Michael L.
AU - Brent, Lauren J.N.
AU - Snyder-Mackler, Noah
AU - Higham, James P.
N1 - Funding: This research was supported by the National Institutes of Health (R01- AG060931, 1F31AG072787-01A1, R01-MH-118203, R56AG071023, R56MH122819, UM1MH130981, U01-MH121260, R01-MH96875, R01-MH089484). LEN is supported by New York University MacCracken Fellowship and the National Science Foundation Graduate Research Fellowship Program (DGE277020). CT was supported by the Blavatnik Family Foundation Fellowship. CT and LEN were also supported by the Animal Models for the Social Dimensions of Health and Aging Research Network.
PY - 2023/1/29
Y1 - 2023/1/29
N2 - Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for integrating observations of social behavior throughout an individual’s life with detailed anatomical, physiological, and molecular measurements. Here, we synthesize the body of research from one such naturalistic study system, Cayo Santiago Island, which is home to the world’s longest continuously monitored free-ranging population of rhesus macaques. We review recent studies of age-related variation in morphology, gene regulation, microbiome composition, and immune function. We also discuss ecological and social modifiers of age-markers in this population. In particular, we summarize how a major natural disaster, Hurricane Maria, affected rhesus macaque physiology and social structure and highlight the context-dependent and domain-specific nature of aging modifiers. Finally, we conclude by providing directions for future study, on Cayo Santiago and elsewhere, that will further our understanding of aging across different domains and how social adversity modifies aging processes.
AB - Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for integrating observations of social behavior throughout an individual’s life with detailed anatomical, physiological, and molecular measurements. Here, we synthesize the body of research from one such naturalistic study system, Cayo Santiago Island, which is home to the world’s longest continuously monitored free-ranging population of rhesus macaques. We review recent studies of age-related variation in morphology, gene regulation, microbiome composition, and immune function. We also discuss ecological and social modifiers of age-markers in this population. In particular, we summarize how a major natural disaster, Hurricane Maria, affected rhesus macaque physiology and social structure and highlight the context-dependent and domain-specific nature of aging modifiers. Finally, we conclude by providing directions for future study, on Cayo Santiago and elsewhere, that will further our understanding of aging across different domains and how social adversity modifies aging processes.
U2 - 10.1101/2023.01.28.525893
DO - 10.1101/2023.01.28.525893
M3 - Preprint
BT - The biology of aging in a social world
PB - bioRxiv
ER -