TY - JOUR
T1 - The biology of aging in a social world
T2 - insights from free-ranging rhesus macaques
AU - Newman, Laura E.
AU - Testard, Camille
AU - DeCasien, Alex R.
AU - Chiou, Kenneth L.
AU - Watowich, Marina M.
AU - Janiak, Mareike C.
AU - Pavez-Fox, Melissa A.
AU - Sanchez-Rosado, Mitchell
AU - Cooper, Eve B.
AU - Costa, Christina E.
AU - Petersen, Rachel M.
AU - Montague, Michael J.
AU - Platt, Michael L.
AU - Brent, Lauren J.N.
AU - Snyder-Mackler, Noah
AU - Higham, James P.
N1 - This research was supported by the National Institutes of Health [R01-AG060931, 1F31AG072787-01A1, R01-MH-118203, R56AG071023, R56MH122819, UM1MH130981, U01-MH121260, R01-MH096875, R01-MH089484] and The Leakey Foundation. LEN is supported by New York University MacCracken Fellowship and the National Science Foundation Graduate Research Fellowship Program [DGE277020]. CT was supported by the Blavatnik Family Foundation Fellowship. CT and LEN were also supported by the Animal Models for the Social Dimensions of Health and Aging Research Network [NIH/NIA R24 AG065172].
PY - 2023/11
Y1 - 2023/11
N2 - Social adversity can increase the age-associated risk of disease and
death, yet the biological mechanisms that link social adversities to
aging remain poorly understood. Long-term naturalistic studies of
nonhuman animals are crucial for integrating observations of social
behavior throughout an individual’s life with detailed anatomical,
physiological, and molecular measurements. Here, we synthesize the body
of research from one such naturalistic study system, Cayo Santiago,
which is home to the world’s longest continuously monitored free-ranging
population of rhesus macaques (Macaca mulatta). We review
recent studies of age-related variation in morphology, gene regulation,
microbiome composition, and immune function. We also discuss ecological
and social modifiers of age-markers in this population. In particular,
we summarize how a major natural disaster, Hurricane Maria, affected
rhesus macaque physiology and social structure and highlight the
context-dependent and domain-specific nature of aging modifiers.
Finally, we conclude by providing directions for future study, on Cayo
Santiago and elsewhere, that will further our understanding of aging
across different domains and how social adversity modifies aging
processes.
AB - Social adversity can increase the age-associated risk of disease and
death, yet the biological mechanisms that link social adversities to
aging remain poorly understood. Long-term naturalistic studies of
nonhuman animals are crucial for integrating observations of social
behavior throughout an individual’s life with detailed anatomical,
physiological, and molecular measurements. Here, we synthesize the body
of research from one such naturalistic study system, Cayo Santiago,
which is home to the world’s longest continuously monitored free-ranging
population of rhesus macaques (Macaca mulatta). We review
recent studies of age-related variation in morphology, gene regulation,
microbiome composition, and immune function. We also discuss ecological
and social modifiers of age-markers in this population. In particular,
we summarize how a major natural disaster, Hurricane Maria, affected
rhesus macaque physiology and social structure and highlight the
context-dependent and domain-specific nature of aging modifiers.
Finally, we conclude by providing directions for future study, on Cayo
Santiago and elsewhere, that will further our understanding of aging
across different domains and how social adversity modifies aging
processes.
KW - Aging
KW - Social behavior
KW - Senescence
KW - Primate
KW - Cayo Santiago
U2 - 10.1016/j.neubiorev.2023.105424
DO - 10.1016/j.neubiorev.2023.105424
M3 - Article
SN - 0149-7634
VL - 154
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105424
ER -