The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation

Leonides Fernandez, Susana Delgado, Helena Herrero, Antonio Maldonado, Juan M. Rodriguez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Eight women with clinical signs of staphylococcal mastitis were randomly divided in 2 groups. A solution of the bacteriocin nisin (6 tg/mQ was applied to the nipple and mammary areola of those assigned to the nisin group for 2 weeks, and a similar preparation devoid of nisin was applied to the control group. On day 0, staphylococcal counts in breast milk of the nisin and control groups were similar (5.04 0.19 and 4.88 0.21 log,0 CFU/mL, respectively). However, on day 14, the mean in the nisin group (3.22 0.43 log,, CFU/mL) was statistically lower than that of the control group (5.01 0.21 log,0 CFU/mL). No clinical signs of mastitis were observed among the women of the nisin group on day 14, whereas they persisted throughout the study in the women of the control group. In conclusion, nisin seems to be an efficient alternative to antibiotics for the treatment of staphylococcal mastitis.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalJournal of human lactation
Volume24
Issue number3
DOIs
Publication statusPublished - Aug 2008

Keywords

  • nisin
  • mastitis
  • Staphylococcus
  • lactation
  • COAGULASE-NEGATIVE STAPHYLOCOCCI
  • AUREUS
  • INHIBITION
  • RESISTANCE
  • EXPRESSION

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