Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior

K Langley, D Turic, F Rice, P Holmans, MBM van den Bree, N Craddock, M Owen, Lindsey Kent, MC O’Donovan, A Thapar

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


Gene x environment (G x E) interactions are increasingly thought to have substantial influence on the actiology and clinical manifestations of complex disorders. In ADHD, although main effects of specific genetic variants and pre-or peri-natal variables have been reported and replicated using pooled analyses, few studies have looked at possible interactions. In a clinical sample of 266 children with ADHD, we tested for interaction between gene variants (in DRD4, DAT1, DRD5, and 5HTT) found to be associated with ADHD in pooled analyses and maternal smoking, alcohol use during pregnancy and birth weight. First, G x E effects on a diagnosis of ADHD were tested using conditional logistic regression analyses. Second, possible modifying effects of G x E on symptoms of associated conduct disorder and oppositional defiant disorder (ODD) were investigated using linear regression analysis. The sample size associated with each of the analyses differed as not each variant had been genotyped for each individual. No effects of G x E on ADHD diagnosis were observed. The results suggest that lower birth weight and maternal smoking during pregnancy may interact with DRD5 and DAT1 (birth weight only) in influencing associated antisocial behavior symptoms (ODD and conduct disorder). These preliminary findings showed no evidence of interaction between previously implicated variants in ADHD and specific environmental risk factors, on diagnosis of the disorder. There may be evidence of G x E on associated antisocial behavior in ADHD, but further investigation is needed. (C) 2007 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalAmerican Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Issue number1
Early online date19 Jun 2007
Publication statusPublished - 5 Jan 2008


  • gene x environment interaction
  • birth weight
  • maternal smoking during pregnancy
  • social class
  • DRD5


Dive into the research topics of 'Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior'. Together they form a unique fingerprint.

Cite this