Telomere length abnormalities in mammalian radiosensitive cells

J McIlrath; SD Bouffler; E Samper; A Cuthbert; A Wojcik; I Szumiel; Peter Edward Bryant; Andrew Clive Riches; A Thompson; MA Blasco; RF Newbold

Telomere length abnormalities in mammalian radiosensitive cells

J McIlrath, SD Bouffler, E Samper, A Cuthbert, A Wojcik, I Szumiel, Peter Edward Bryant, Andrew Clive Riches, A Thompson, MA Blasco, RF Newbold

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization, Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal radiosensitivity, In agreement with this hypothesis, a significant inverse correlation between telomere length and chromosomal radiosensitivity was observed in lymphocytes from 24 breast cancer patients and 5 normal individuals. In contrast, no chromosomal radiosensitivity was observed in mouse cell lines that showed shortened telomeres, possibly reflecting differences in radiation responses between primary cells and established cell lines. Telomere Length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked.

Original language	English
Pages (from-to)	912-915
Number of pages	4
Journal	Cancer Research
Volume	61
Publication status	Published - 1 Feb 2001

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SDG 3 Good Health and Well-being

Keywords

MICE

Cite this

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title = "Telomere length abnormalities in mammalian radiosensitive cells",

abstract = "Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization, Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal radiosensitivity, In agreement with this hypothesis, a significant inverse correlation between telomere length and chromosomal radiosensitivity was observed in lymphocytes from 24 breast cancer patients and 5 normal individuals. In contrast, no chromosomal radiosensitivity was observed in mouse cell lines that showed shortened telomeres, possibly reflecting differences in radiation responses between primary cells and established cell lines. Telomere Length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked.",

keywords = "MICE",

author = "J McIlrath and SD Bouffler and E Samper and A Cuthbert and A Wojcik and I Szumiel and Bryant, \{Peter Edward\} and Riches, \{Andrew Clive\} and A Thompson and MA Blasco and RF Newbold",

year = "2001",

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language = "English",

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journal = "Cancer Research",

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TY - JOUR

T1 - Telomere length abnormalities in mammalian radiosensitive cells

AU - McIlrath, J

AU - Bouffler, SD

AU - Samper, E

AU - Cuthbert, A

AU - Wojcik, A

AU - Szumiel, I

AU - Bryant, Peter Edward

AU - Riches, Andrew Clive

AU - Thompson, A

AU - Blasco, MA

AU - Newbold, RF

PY - 2001/2/1

Y1 - 2001/2/1

N2 - Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization, Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal radiosensitivity, In agreement with this hypothesis, a significant inverse correlation between telomere length and chromosomal radiosensitivity was observed in lymphocytes from 24 breast cancer patients and 5 normal individuals. In contrast, no chromosomal radiosensitivity was observed in mouse cell lines that showed shortened telomeres, possibly reflecting differences in radiation responses between primary cells and established cell lines. Telomere Length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked.

AB - Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization, Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal radiosensitivity, In agreement with this hypothesis, a significant inverse correlation between telomere length and chromosomal radiosensitivity was observed in lymphocytes from 24 breast cancer patients and 5 normal individuals. In contrast, no chromosomal radiosensitivity was observed in mouse cell lines that showed shortened telomeres, possibly reflecting differences in radiation responses between primary cells and established cell lines. Telomere Length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked.

KW - MICE

UR - https://www.scopus.com/pages/publications/0035117940

M3 - Article

SN - 0008-5472

VL - 61

SP - 912

EP - 915

JO - Cancer Research

JF - Cancer Research

ER -

Telomere length abnormalities in mammalian radiosensitive cells

Abstract

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Keywords

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