Abstract
A recent resurgence in the use of compounds to study essential biological processes raises important questions concerning the link between fundamental research and drug development. This article discusses many of the issues involved, in the context of host cell invasion and egress by parasites of the Phylum Apicomplexa. In addition, an overview of the key steps in invasion and egress is provided with a particular emphasis on potential parasite protein drug targets.
| Original language | English |
|---|---|
| Pages (from-to) | 61-74 |
| Number of pages | 14 |
| Journal | Infectious Disorders - Drug Targets |
| Volume | 8 |
| Publication status | Published - Jan 2007 |
Keywords
- apicomplexa
- invasion
- egress
- Toxoplasma
- Plasmodium
- chemical genetics
- drug discovery
- inhibitors
- HOST-CELL INVASION
- APICAL MEMBRANE ANTIGEN-1
- NUCLEOSIDE TRIPHOSPHATE HYDROLASE
- PARASITOPHOROUS VACUOLE MEMBRANE
- TOXOPLASMA-GONDII TACHYZOITES
- PLASMODIUM-FALCIPARUM ACTIN
- STAGE MALARIA PARASITES
- SMALL-MOLECULE APPROACH
- RED-BLOOD-CELLS
- APICOMPLEXAN PARASITES
