Targeting invasion and egress: From tools to drugs?

R. E. Morgan, K. M. Evans, S. Patterson, F. Catti, G. E. Ward, N. J. Westwood

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

A recent resurgence in the use of compounds to study essential biological processes raises important questions concerning the link between fundamental research and drug development. This article discusses many of the issues involved, in the context of host cell invasion and egress by parasites of the Phylum Apicomplexa. In addition, an overview of the key steps in invasion and egress is provided with a particular emphasis on potential parasite protein drug targets.

Original languageEnglish
Pages (from-to)61-74
Number of pages14
JournalInfectious Disorders - Drug Targets
Volume8
Publication statusPublished - Jan 2007

Keywords

  • apicomplexa
  • invasion
  • egress
  • Toxoplasma
  • Plasmodium
  • chemical genetics
  • drug discovery
  • inhibitors
  • HOST-CELL INVASION
  • APICAL MEMBRANE ANTIGEN-1
  • NUCLEOSIDE TRIPHOSPHATE HYDROLASE
  • PARASITOPHOROUS VACUOLE MEMBRANE
  • TOXOPLASMA-GONDII TACHYZOITES
  • PLASMODIUM-FALCIPARUM ACTIN
  • STAGE MALARIA PARASITES
  • SMALL-MOLECULE APPROACH
  • RED-BLOOD-CELLS
  • APICOMPLEXAN PARASITES

Fingerprint

Dive into the research topics of 'Targeting invasion and egress: From tools to drugs?'. Together they form a unique fingerprint.

Cite this