Target-driven selection in a dynamic nitrone library

Simon M. Turega; Christiane Lorenz; Jan W. Sadownik; Douglas Philp

doi:10.1039/b805945d

Target-driven selection in a dynamic nitrone library

Simon M. Turega
, Christiane Lorenz
, Jan W. Sadownik
, Douglas Philp

Research output: Contribution to journal › Article › peer-review

Abstract

Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.

Original language	English
Pages (from-to)	4076-4078
Number of pages	3
Journal	Chemical Communications
Issue number	34
DOIs	https://doi.org/10.1039/b805945d
Publication status	Published - 14 Sept 2008

Keywords

COMBINATORIAL LIBRARIES
CHEMISTRY
AMPLIFICATION
RECEPTORS
DISCOVERY
SENSORS
SYSTEM

Access to Document

10.1039/b805945d

Handle.net

Persistent link to portal record

Cite this

@article{3015b6db2d89477283df2704e382486e,

title = "Target-driven selection in a dynamic nitrone library",

abstract = "Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.",

keywords = "COMBINATORIAL LIBRARIES, CHEMISTRY, AMPLIFICATION, RECEPTORS, DISCOVERY, SENSORS, SYSTEM",

author = "Turega, \{Simon M.\} and Christiane Lorenz and Sadownik, \{Jan W.\} and Douglas Philp",

year = "2008",

month = sep,

day = "14",

doi = "10.1039/b805945d",

language = "English",

pages = "4076--4078",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "34",

}

TY - JOUR

T1 - Target-driven selection in a dynamic nitrone library

AU - Turega, Simon M.

AU - Lorenz, Christiane

AU - Sadownik, Jan W.

AU - Philp, Douglas

PY - 2008/9/14

Y1 - 2008/9/14

N2 - Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.

AB - Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.

KW - COMBINATORIAL LIBRARIES

KW - CHEMISTRY

KW - AMPLIFICATION

KW - RECEPTORS

KW - DISCOVERY

KW - SENSORS

KW - SYSTEM

UR - https://www.scopus.com/pages/publications/50849141689

U2 - 10.1039/b805945d

DO - 10.1039/b805945d

M3 - Article

SN - 1359-7345

SP - 4076

EP - 4078

JO - Chemical Communications

JF - Chemical Communications

IS - 34

ER -

Target-driven selection in a dynamic nitrone library

Abstract

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

EPSRC: PROBING CROSSCATALYSIS: Probing Crosscatalysis, Autocatalysis and Amplific

Cite this

Target-driven selection in a dynamic nitrone library

Abstract

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

Projects

EPSRC: PROBING CROSSCATALYSIS: Probing Crosscatalysis, Autocatalysis and Amplific

Cite this