Target-driven selection in a dynamic nitrone library

Simon M. Turega; Christiane Lorenz; Jan W. Sadownik; Douglas Philp

doi:10.1039/b805945d

Target-driven selection in a dynamic nitrone library

Simon M. Turega, Christiane Lorenz, Jan W. Sadownik, Douglas Philp

Research output: Contribution to journal › Article › peer-review

Abstract

Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.

Original language	English
Pages (from-to)	4076-4078
Number of pages	3
Journal	Chemical Communications
Issue number	34
DOIs	https://doi.org/10.1039/b805945d
Publication status	Published - 14 Sept 2008

Keywords

COMBINATORIAL LIBRARIES
CHEMISTRY
AMPLIFICATION
RECEPTORS
DISCOVERY
SENSORS
SYSTEM

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10.1039/b805945d

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title = "Target-driven selection in a dynamic nitrone library",

abstract = "Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.",

keywords = "COMBINATORIAL LIBRARIES, CHEMISTRY, AMPLIFICATION, RECEPTORS, DISCOVERY, SENSORS, SYSTEM",

author = "Turega, {Simon M.} and Christiane Lorenz and Sadownik, {Jan W.} and Douglas Philp",

year = "2008",

month = sep,

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doi = "10.1039/b805945d",

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journal = "Chemical Communications",

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AU - Lorenz, Christiane

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AU - Philp, Douglas

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AB - Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination, this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.

KW - COMBINATORIAL LIBRARIES

KW - CHEMISTRY

KW - AMPLIFICATION

KW - RECEPTORS

KW - DISCOVERY

KW - SENSORS

KW - SYSTEM

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JO - Chemical Communications

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Target-driven selection in a dynamic nitrone library

Abstract

Keywords

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EPSRC: PROBING CROSSCATALYSIS: Probing Crosscatalysis, Autocatalysis and Amplific

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Target-driven selection in a dynamic nitrone library

Abstract

Keywords

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Projects

EPSRC: PROBING CROSSCATALYSIS: Probing Crosscatalysis, Autocatalysis and Amplific

Cite this