Tandem termination signals: myth or reality?

LL Major, TD Edgar, PY Yip, LA Isaksson, WP Tate

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


In two Escherichia coli genomes, laboratory strain K-12 and pathological strain O157:H7, tandem termination codons as a group are slightly over-represented as termination signals. Individually however, they span the range of representations, over, as expected, or under, in one or both of the strains. In vivo, tandem termination codons do not make more efficient signals. The second codon can act as a backstop where readthrough of the first has occurred, but not at the expected efficiency. UGAUGA remains an enigma, highly over-represented, but with the second UGA a relatively inefficient back up stop codon. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalFEBS Letters
Issue number1, SI
Publication statusPublished - 6 Mar 2002


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