Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes

Craig D. Campbell, Nicolas Duguet, Katherine A. Gallagher, Jennifer E. Thomson, Anita G. Lindsay, AnnMarie C. O'Donoghue, Andrew D. Smith

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (+/-)-4-phenoxycarbonylazlactones in good isolated yields (66-84%) from the corresponding N-p-anisoyl amino acids.

Original languageEnglish
Pages (from-to)3528-3530
Number of pages3
JournalChemical Communications
Issue number30
DOIs
Publication statusPublished - 2008

Keywords

  • ORGANIC-SYNTHESIS
  • DOMINO REACTIONS
  • QUATERNARY CARBON
  • ORGANOCATALYSIS
  • CONSTRUCTION
  • STRATEGIES
  • CATALYSIS
  • BENZOFURANONES
  • AZLACTONES
  • ACYLATION

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