Systemic absorption of ketoconazole from vaginal pessaries

M D Ene, P J Williamson, T K Daneshmend, N R Blatchford

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Eight healthy female subjects were each given (a) ketoconazole 400 mg orally, (b) ketoconazole 400 mg as a single vaginal pessary, (c) ketoconazole 800 mg as two vaginal pessaries, and (d) ketoconazole 1200 mg as three vaginal pessaries. The area under the plasma concentration time curve (AUC) after the oral dose was 51.41 +/- 10.99 mg l-1 h (mean +/- s.d.) and the half-life of ketoconazole was 2.98 +/- 1.41 h. The AUCs after vaginal administration were 0.27 +/- 0.14, 0.52 +/- 0.25, and 0.43 +/- 0.22 mg-1 l h following the 400, 800 and 1200 mg pessaries respectively. Systemic absorption of single doses of vaginally administered ketoconazole appears to be negligible in the absence of vaginal infection. There were no local or systemic side effects related to ketoconazole in these healthy volunteers.

Original languageEnglish
Pages (from-to)173-5
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume17
Issue number2
Publication statusPublished - Feb 1984

Keywords

  • Absorption
  • Administration, Oral
  • Adult
  • Female
  • Humans
  • Ketoconazole/administration & dosage

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