20.500.12556/RUL-148276
What is relative survival and what is its role in haematology?
In many haematological diseases, the survival probability is the key outcome. However, when the population of patients is rather old and the follow-up long, a significant proportion of deaths cannot be attributed to the studied disease. This lessens the importance of common survival analysis measures like overall survival and shows the need for other outcome measures requiring more complex methodology. When disease-specific information is of interest but the cause of death is not available in the data, relative survival methodology becomes crucial. The idea of relative survival is to merge the observed data set with the mortality data in the general population and thus allow for an indirect estimation of the burden of the disease.
In this work, an overview of different measures that can be of interest in the field of haematology is given. We introduce the crude mortality that reports the probability of dying due to the disease of interest; the net survival that focuses on excess hazard alone and presents the key measure in comparing the disease burden of patients from populations with different general population mortality; and the relative survival ratio which gives a simple comparison of the patients' and the general population survival. We explain the properties of each measure, and some brief notes are given on estimation. Furthermore, we describe how association with covariates can be studied. All the methods and their estimators are illustrated on a sub-cohort of older patients who received a first allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes or secondary acute myeloid leukemia, to show how different methods can provide different insights into the data.
survival analysis
haematological diseases
mortality tables
relative survival
net survival
competing risks
analiza preživetja
hematološke bolezni
tabele smrtnosti
true
false
true
Angleški jezik
Slovenski jezik
Članek v reviji
2023-08-09 11:59:30
2023-08-09 11:59:37
2023-08-10 03:36:57
0000-00-00 00:00:00
2023
0
0
11 str.
iss. 2, art. 101474
Vol. 36
2023
0000-00-00
Zaloznikova
Objavljeno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
616.1
1532-1924
10.1016/j.beha.2023.101474
151566851
1-s2.0-S152169262300035X-main.pdf
1-s2.0-S152169262300035X-main.pdf
1
C93F7767ECE742D5115AB0F108B58254
e75fb6fbf12ac4d8d01ff46424039410f5ab384a023da450f3c5f5e26c7d7aa4
d72dd7f4-369b-11ee-aeaf-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172356
https://www.sciencedirect.com/science/article/pii/S152169262300035X
0
6abbf963-369b-11ee-aeaf-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172355
Medicinska fakulteta
0
0
0