Systematic review of the efficacy and safety of using mesh in surgery for uterine or vaginal vault prolapse

Xueli Jia, Cathryn Glazener, Graham Mowatt, David Jenkinson, Cynthia Fraser, Christine Bain, Jennifer Burr

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

Introduction and hypothesis The aim of this study is to estimate efficacy and safety of mesh in surgery for uterine or vault prolapse

Methods Seventeen electronic databases were searched for relevant studies that were published from 1980 onwards

Results Fifty-four studies involving 7,054 women were included. For sacrocolpopexy (average follow-up 23 months), the risk of clinical recurrence ranged from 0% to 6%, persistent symptoms ranged from 3% to 31% and mesh erosion from 0% to 12%. For infracoccygeal sacropexy (average follow-up 13 months), the risk of clinical recurrence ranged from 0% to 25%, persistent symptoms from 2% to 21% and mesh erosion 0% to 21%. Limited evidence was available for sacrocolpopenneopexy and uterine suspension sling to draw reliable estimates

Conclusions Sacrocolpopexy was associated with a low risk of recurrence but with a relatively high risk of mesh erosion Ranges of estimates for outcomes for other mesh techniques were wide

Original languageEnglish
Pages (from-to)1413-1431
Number of pages19
JournalInternational Urogynecology Journal
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Efficacy
  • Mesh
  • Mesh erosion
  • NICE
  • Pelvic organ prolapsed
  • Safety
  • Systematic review
  • ABDOMINAL SACRAL COLPOPEXY
  • POSTERIOR INTRAVAGINAL SLINGPLASTY
  • PELVIC ORGAN PROLAPSE
  • TERM-FOLLOW-UP
  • SYNTHETIC MESH
  • INFRACOCCYGEAL SACROPEXY
  • UTEROVAGINAL PROLAPSE
  • SACROSPINOUS COLPOPEXY
  • GENITAL PROLAPSE
  • YOUNG-WOMEN

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