Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction

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Abstract

A late stage Diels-Alder reaction is used to prepare a mixture of JBIR-22, a natural product from the Equisetin family of tetramic acids, and one of its diastereomers. This is achieved in just 8 steps from pyruvate. The success of the late stage DA approach is discussed in the context of the biosynthesis of JBIR-22 (and perhaps related natural products).
Original languageEnglish
Pages (from-to)10527-10531
JournalOrganic & Biomolecular Chemistry
Volume13
Issue number42
Early online date25 Aug 2015
DOIs
Publication statusPublished - 14 Nov 2015

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