Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Michael P. Van Ryssen, Nicolaos Avlonitis, Rashid Giniatullin, Craig McDougall, James L. Carr, Megan N. Stanton-Humphreys, Emma L. A. Borgstroem, C Tom A Brown, Dmitriy Fayuk, Alexander Surin, Minna Niittykoski, Leonard Khiroug, Stuart J. Conway

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.

Original languageEnglish
Pages (from-to)4695-4707
Number of pages13
JournalOrganic & Biomolecular Chemistry
Volume7
Issue number22
DOIs
Publication statusPublished - 2009

Keywords

  • VANILLOID RECEPTOR TRPV1
  • ANALGESIC AGENTS
  • ION CHANNELS
  • CAPSAICIN
  • NEURONS
  • ANALOGS
  • REGION
  • PAIN
  • RESINIFERATOXIN
  • CHEMISTRY

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