Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Michael P. Van Ryssen; Nicolaos Avlonitis; Rashid Giniatullin; Craig McDougall; James L. Carr; Megan N. Stanton-Humphreys; Emma L. A. Borgstroem; C Tom A Brown; Dmitriy Fayuk; Alexander Surin; Minna Niittykoski; Leonard Khiroug; Stuart J. Conway

doi:10.1039/b914981c

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Michael P. Van Ryssen, Nicolaos Avlonitis, Rashid Giniatullin, Craig McDougall, James L. Carr, Megan N. Stanton-Humphreys, Emma L. A. Borgstroem, C Tom A Brown, Dmitriy Fayuk, Alexander Surin, Minna Niittykoski, Leonard Khiroug, Stuart J. Conway

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.

Original language	English
Pages (from-to)	4695-4707
Number of pages	13
Journal	Organic & Biomolecular Chemistry
Volume	7
Issue number	22
DOIs	https://doi.org/10.1039/b914981c
Publication status	Published - 2009

Keywords

VANILLOID RECEPTOR TRPV1
ANALGESIC AGENTS
ION CHANNELS
CAPSAICIN
NEURONS
ANALOGS
REGION
PAIN
RESINIFERATOXIN
CHEMISTRY

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10.1039/b914981c

Cite this

Van Ryssen, M. P., Avlonitis, N., Giniatullin, R., McDougall, C., Carr, J. L., Stanton-Humphreys, M. N., Borgstroem, E. L. A., Brown, C. T. A., Fayuk, D., Surin, A., Niittykoski, M., Khiroug, L., & Conway, S. J. (2009). Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists. Organic & Biomolecular Chemistry, 7(22), 4695-4707. https://doi.org/10.1039/b914981c

@article{427fef304f444bb1a170a947f917cbe3,

title = "Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists",

abstract = "The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.",

keywords = "VANILLOID RECEPTOR TRPV1, ANALGESIC AGENTS, ION CHANNELS, CAPSAICIN, NEURONS, ANALOGS, REGION, PAIN, RESINIFERATOXIN, CHEMISTRY",

author = "{Van Ryssen}, {Michael P.} and Nicolaos Avlonitis and Rashid Giniatullin and Craig McDougall and Carr, {James L.} and Stanton-Humphreys, {Megan N.} and Borgstroem, {Emma L. A.} and Brown, {C Tom A} and Dmitriy Fayuk and Alexander Surin and Minna Niittykoski and Leonard Khiroug and Conway, {Stuart J.}",

year = "2009",

doi = "10.1039/b914981c",

language = "English",

volume = "7",

pages = "4695--4707",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0539",

publisher = "Royal Society of Chemistry",

number = "22",

}

Van Ryssen, MP, Avlonitis, N, Giniatullin, R, McDougall, C, Carr, JL, Stanton-Humphreys, MN, Borgstroem, ELA, Brown, CTA, Fayuk, D, Surin, A, Niittykoski, M, Khiroug, L & Conway, SJ 2009, 'Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists', Organic & Biomolecular Chemistry, vol. 7, no. 22, pp. 4695-4707. https://doi.org/10.1039/b914981c

TY - JOUR

T1 - Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

AU - Van Ryssen, Michael P.

AU - Avlonitis, Nicolaos

AU - Giniatullin, Rashid

AU - McDougall, Craig

AU - Carr, James L.

AU - Stanton-Humphreys, Megan N.

AU - Borgstroem, Emma L. A.

AU - Brown, C Tom A

AU - Fayuk, Dmitriy

AU - Surin, Alexander

AU - Niittykoski, Minna

AU - Khiroug, Leonard

AU - Conway, Stuart J.

PY - 2009

Y1 - 2009

N2 - The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.

AB - The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.

KW - VANILLOID RECEPTOR TRPV1

KW - ANALGESIC AGENTS

KW - ION CHANNELS

KW - CAPSAICIN

KW - NEURONS

KW - ANALOGS

KW - REGION

KW - PAIN

KW - RESINIFERATOXIN

KW - CHEMISTRY

UR - http://www.scopus.com/inward/record.url?scp=70350686146&partnerID=8YFLogxK

U2 - 10.1039/b914981c

DO - 10.1039/b914981c

M3 - Article

SN - 1477-0539

VL - 7

SP - 4695

EP - 4707

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 22

ER -

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Abstract

Keywords

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Tools & Res 2006 BB/E005756/1: The design, synthesis and biological application of tools to enable the wavelength-dependent control of receptor activation and inhibition

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Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Abstract

Keywords

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Projects

Tools & Res 2006 BB/E005756/1: The design, synthesis and biological application of tools to enable the wavelength-dependent control of receptor activation and inhibition

Cite this