Projects per year
Abstract
A stereoselective synthesis of the proposed structure of palmerolide C (2), a cytotoxic marine macrolide isolated from the Antarctic tunicate Synoicum adareanum, utilizes a convergent carbonyl-based coupling strategy to construct the C1-C24 carbon skeleton. Compound 2 was shown to be a diastereomer of palmerolide C, and the structural revision of the natural product is proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 14250-14254 |
| Number of pages | 5 |
| Journal | Chemistry - A European Journal |
| Volume | 18 |
| Issue number | 45 |
| DOIs | |
| Publication status | Published - 5 Nov 2012 |
Keywords
- REVISED STRUCTURES
- VINYLOGOUS ALDOL
- structure elucidation
- natural products
- melanoma
- CHEMICAL-SYNTHESIS
- FRAGMENT
- total synthesis
- COUPLING-CONSTANTS
- macrolide
- TUNICATE SYNOICUM-ADAREANUM
- ACYCLIC STRUCTURES
- NATURAL-PRODUCTS
- FORMAL TOTAL-SYNTHESIS
- BIOLOGICAL EVALUATION
Access to Document
Fingerprint
Dive into the research topics of 'Synthesis of the Originally Proposed Structure of Palmerolide C'. Together they form a unique fingerprint.Projects
- 3 Finished
-
RS Uni Research Fellowship Renewal 2010: University Research Fellowship - New Methods and Strategies for the Synthesis of Bioactive Natural Products
Florence, G. J. (PI)
1/10/10 → 30/09/13
Project: Fellowship
-
Synthesis of Palmerolides EP/F011458/1: Synthesis of the Palmerolides
Florence, G. J. (PI)
1/11/07 → 30/04/11
Project: Standard
-
The Royal Society 516002.K501/kk: Dr G Florence research fellowship application - 2005
Florence, G. J. (PI)
1/10/05 → 30/09/10
Project: Fellowship