Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

R Alan Aitken; Anna Meehan; Lynn Anita Power

doi:10.1055/s-0034-1380511

Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

R Alan Aitken, Anna Meehan, Lynn Anita Power

Research output: Contribution to journal › Article › peer-review

Abstract

A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.

Original language	English
Pages (from-to)	1557-1559
Number of pages	3
Journal	Synthesis
Volume	47
Issue number	11
Early online date	2 Apr 2015
DOIs	https://doi.org/10.1055/s-0034-1380511
Publication status	Published - 1 Jun 2015

Keywords

Chiral pool
Stereoselective synthesis
(R)-lactic acid
(R)-alanine
Diazotization
1,3-dioxolan-4-one

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10.1055/s-0034-1380511

Aitken_2015_Syn_Synthesis_AM
© Georg Thieme Verlag Stuttgart - New York. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at http://dx.doi.org/10.1055/s-0034-1380511
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Cite this

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title = "Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one",

abstract = "A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.",

keywords = "Chiral pool, Stereoselective synthesis, (R)-lactic acid, (R)-alanine, Diazotization, 1,3-dioxolan-4-one ",

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AU - Meehan, Anna

AU - Power, Lynn Anita

PY - 2015/6/1

Y1 - 2015/6/1

N2 - A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.

AB - A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.

KW - Chiral pool

KW - Stereoselective synthesis

KW - (R)-lactic acid

KW - (R)-alanine

KW - Diazotization

KW - 1,3-dioxolan-4-one

U2 - 10.1055/s-0034-1380511

DO - 10.1055/s-0034-1380511

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ER -

Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

Abstract

Keywords

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