Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

R Alan Aitken, Anna Meehan, Lynn Anita Power

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
1 Downloads (Pure)

Abstract

A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.
Original languageEnglish
Pages (from-to)1557-1559
Number of pages3
JournalSynthesis
Volume47
Issue number11
Early online date2 Apr 2015
DOIs
Publication statusPublished - 1 Jun 2015

Keywords

  • Chiral pool
  • Stereoselective synthesis
  • (R)-lactic acid
  • (R)-alanine
  • Diazotization
  • 1,3-dioxolan-4-one

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