Synthesis of pyrazines and quinoxalines via acceptorless dehydrogenative coupling routes catalyzed by manganese pincer complexes

Prosenjit Daw, Amit Kumar, Noel A. E. Jalapa, Yael Diskin-Posner, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.
Original languageEnglish
Pages (from-to)7734-7741
JournalACS Catalysis
Volume8
Issue number9
Early online date23 Jul 2018
DOIs
Publication statusPublished - 7 Sept 2018

Keywords

  • Manganese
  • Pincer
  • Pyrazine
  • Quinoxaline
  • Dehydrogenative coupling

Fingerprint

Dive into the research topics of 'Synthesis of pyrazines and quinoxalines via acceptorless dehydrogenative coupling routes catalyzed by manganese pincer complexes'. Together they form a unique fingerprint.

Cite this