Synthesis of phosphonate and phostone analogues of ribose-1-phosphates

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Abstract

The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the alpha- and beta-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose series and a synthesis of the corresponding cyclic phostones of each alpha-ribose is also reported. These compounds have been prepared as tools to probe the details of fluorometabolism in S. cattleya.

Original languageEnglish
Article number37
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume5
DOIs
Publication statusPublished - 27 Jul 2009

Keywords

  • 5-fluoro-5-deoxyribose-1-phosphate
  • fluorometabolite biosynthesis
  • phosphonates
  • phostone
  • ribose-1-phosphate
  • Biosynthesis
  • Fluorinase
  • Acid

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