Synthesis of Phosphinic Acid Transition State Analogues for the Reaction Catalysed by Kynureninase

Nigel Peter Botting; Fiona C Ross; Paul D Leeson

Synthesis of Phosphinic Acid Transition State Analogues for the Reaction Catalysed by Kynureninase

Nigel Peter Botting, Fiona C Ross, Paul D Leeson

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The syntheses of phosphinic acid and methyl phosphinate analogues of kynurenine, designed as transition state mimics for the enzyme kynureninase ate described, along with their inhibitory properties. Copyright (C) 1996 Elsevier Science Ltd

Original language	English
Pages (from-to)	2643-2646
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Publication status	Published - 19 Nov 1996

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title = "Synthesis of Phosphinic Acid Transition State Analogues for the Reaction Catalysed by Kynureninase",

abstract = "The syntheses of phosphinic acid and methyl phosphinate analogues of kynurenine, designed as transition state mimics for the enzyme kynureninase ate described, along with their inhibitory properties. Copyright (C) 1996 Elsevier Science Ltd",

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T1 - Synthesis of Phosphinic Acid Transition State Analogues for the Reaction Catalysed by Kynureninase

AU - Botting, Nigel Peter

AU - Ross, Fiona C

AU - Leeson, Paul D

PY - 1996/11/19

Y1 - 1996/11/19

N2 - The syntheses of phosphinic acid and methyl phosphinate analogues of kynurenine, designed as transition state mimics for the enzyme kynureninase ate described, along with their inhibitory properties. Copyright (C) 1996 Elsevier Science Ltd

AB - The syntheses of phosphinic acid and methyl phosphinate analogues of kynurenine, designed as transition state mimics for the enzyme kynureninase ate described, along with their inhibitory properties. Copyright (C) 1996 Elsevier Science Ltd

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M3 - Article

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SP - 2643

EP - 2646

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

Synthesis of Phosphinic Acid Transition State Analogues for the Reaction Catalysed by Kynureninase

Abstract

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