Synthesis of Phenylglycine Derivatives as Potent and Selective Antagonists of Group III Metabotropic Glutamate Receptors

Stuart John Conway; JC Miller; PA Howson; BP Clark; DE Jane

Synthesis of Phenylglycine Derivatives as Potent and Selective Antagonists of Group III Metabotropic Glutamate Receptors

Stuart John Conway, JC Miller, PA Howson, BP Clark, DE Jane

School of Chemistry

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	777-780
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Publication status	Published - 26 Mar 2001

Keywords

RAT SPINAL-CORD
MOTONEURONS
SUBTYPES

Cite this

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title = "Synthesis of Phenylglycine Derivatives as Potent and Selective Antagonists of Group III Metabotropic Glutamate Receptors",

abstract = "The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.",

keywords = "RAT SPINAL-CORD, MOTONEURONS, SUBTYPES",

author = "Conway, {Stuart John} and JC Miller and PA Howson and BP Clark and DE Jane",

note = "Address is Department of Pharmacology, University of Bristol",

year = "2001",

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language = "English",

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pages = "777--780",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis of Phenylglycine Derivatives as Potent and Selective Antagonists of Group III Metabotropic Glutamate Receptors

AU - Conway, Stuart John

AU - Miller, JC

AU - Howson, PA

AU - Clark, BP

AU - Jane, DE

N1 - Address is Department of Pharmacology, University of Bristol

PY - 2001/3/26

Y1 - 2001/3/26

N2 - The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

AB - The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - RAT SPINAL-CORD

KW - MOTONEURONS

KW - SUBTYPES

UR - http://www.scopus.com/inward/record.url?scp=0035953077&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 777

EP - 780

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

Synthesis of Phenylglycine Derivatives as Potent and Selective Antagonists of Group III Metabotropic Glutamate Receptors

Abstract

Keywords

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