Synthesis of next generation maleimide radical labels

Bouchra Hajjaj, Anokhi Shah, Stacey Bell, Sally Lorna Shirran, Catherine Helen Botting, Alexandra Martha Zoya Slawin, Alison Hulme, Janet Eleanor Lovett

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
Original languageEnglish
Article number27
Pages (from-to)2357-2361
Number of pages5
JournalSynlett
Early online date5 Jul 2016
DOIs
Publication statusPublished - Oct 2016

Keywords

  • Next-generation maleimide
  • Succinimide
  • Nitroxide spin label
  • Radical
  • EPR spectroscopy

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